Steroids and derivatives
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 10mM (in 1mL DMSO)
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Apexbio Technology LLC Estrone 53-16-7 5g
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases
Cambridge Isotope Laboratories Sodium L-lactate (3 3 3-D3 98%) 20% w/w in water 0 25g/comp
Sodium L-lactate (3 3 3-D3 98%) 20% w/w in water 0 25g/comp
Medchemexpress LLC 1-Methylinosine-d3 (N1-Methylinosine-d3) | 2140-73-0 | 99.0% | 285.27 | 10 MG
1-Methylinosine-d3 is the deuterium-labeled form of 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA, located 3' to the anticodon of eukaryotic tRNA. Deuterium labeling, as seen in this compound, has gained attention for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- It can be used as a tracer in research applications.
- It serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as deuterium, are incorporated into drug molecules for quantitation during drug development.
Medchemexpress LLC Bazedoxifene acetate | 198481-33-3 | MFCD09260074 | 99% | C32H38N2O5 | 100 MG
Bazedoxifene acetate, also known as TSE-424 (acetate)-B, is the B-crystal form compound of Bazedoxifene acetate. It functions as an orally active, nonsteroidal selective estrogen receptor modulator (SERM). This product is intended for research use only.
- Orally active, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM for ERα and 99 nM for ERβ
- Ships at room temperature
- Store at 4°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 50 mg/mL
Cambridge Isotope Laboratories 25-Hydroxyvitamin D3 (unlabeled) 100 ug/mL in ethanol 1 mL
25-Hydroxyvitamin D3 (unlabeled) 100 ug/mL in ethanol 1 mL
Cambridge Isotope Laboratories Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Cambridge Isotope Laboratories ( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Medchemexpress LLC Octaarginine acetate | 98.3% | 1267.50 | 50 MG
Octaarginine acetate | 98.3% | 1267.50 | 50 MG
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 10 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Inhibits estrone sulfatase with an IC50 of 251 nM.
- Inhibits estrone sulfatase with a Ki of 133 nM.
- Potent and long-acting.
- Orally active.
- For research use only.
Selleck Chemical LLC Cortisone
Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress It suppresses the immune system thus reducing inflammation and attendant pain and swelling at the site of the injury
Medchemexpress LLC Petrelintide acetate | 99.8% | 4191.69 (free base) | 1 MG
Petrelintide acetate is a dual amylin and calcitonin receptor agonist (DACRA). It elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, leading to a loss of fat mass while preserving lean mass during weight reduction. It can be used in diabetes research.
- Dual amylin and calcitonin receptor agonist (DACRA)
- Selectively reduces high-fat diet intake
- Promotes fat mass loss while preserving lean mass
- Potential application in diabetes research
Medchemexpress LLC Ibuprofen-d3 | 121662-14-4 | 99.94% | C13H15D3O2 | 50 MG
Ibuprofen-d3 is a deuterium labeled Ibuprofen, acting as a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM. It incorporates stable heavy isotopes, such as deuterium, into drug molecules as tracers for quantitation during drug development. This process has the potential to affect pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | 486.64 | 5 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is intended for research use only.
- Down-regulates GR transcript in hCMEC/D3 cells in a dose-dependent manner.
- Supplementation leads to a significant increase in TER across the hCMEC/D3 monolayer.
- Treated dendritic cells (DCs) exhibit decreased expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83.
- Treated dendritic cells (DCs) show strongly reduced IL-12 secretion.
- Treated dendritic cells (DCs) inhibit IFN-γ production but induce increased release of IL-4.
- Reduces post-ischemic oxidative stress, perfusion pressure, and transudate formation.
- Inhibits post-ischemic shedding of syndecan-1, heparan sulfate, and hyaluronan.
- Inhibits histamine release from mast cells.